International scientific publications        21 July 2017        1916         Comments Off on Effect of metformin and oral contraceptives on polycystic ovary syndrome and IVF cycles

Effect of metformin and oral contraceptives on polycystic ovary syndrome and IVF cycles



The aim of this study is to investigate the effect of metformin and/or OC added to the treatment of PCOS patients at our clinic on IVF outcome.

Materials and methods

This study is a retrospective study that assesses the data of PCOS patients who received IVF between 2005 and 2015 at a private IVF center. The study included 496 PCOS cases aged between 24 and 40. Participants diagnosed with PCOS were divided into 4 groups according to the use of metformin and OC prior to the IVF cycle: 11.1% were in the metformin group, 31.3% in the OC group, 14.9% in the Metformin + OC group, and 42.7% in the control group.


No difference was found in the total gonadotropin dose and duration of stimulation between the groups. Clinical pregnancy rates and implantation rates were similar in all groups, although the numbers of oocytes, mature oocytes, fertilized oocytes, and transferred embryos were lower in the treatment groups received metformin compared to the OC group and control group. There was no significant difference in the presence of OHSS and the singleton and multiple pregnancies between the four groups.


The present study established no positive role of metformin and OC use in increasing the treatment success in IVF/ICSI cycles in PCOS patients. It would be appropriate to limit the use of these agents with special indications such as decreasing insulin resistance or synchronizing follicular cohort.

Keywords: Metformin, Oral, contraceptive, PCOS, IVF, Infertility

M. N. Kalem, Z. Kalem, T. Gurgan

Journal of Endocrinological Investigation , Volume 40, Issue 7, pp 745−752

DOI: 10.1007/s40618−017−0634-x

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